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I wish Mini would steal a page here from their BMW owners and stick a button on the steering wheel so you could flick it into go mode whenever you spot a twisty bit of road. For these analyses, the metformin plus sulfonylurea combination treatment group served as our reference category (usual guideline recommended care).1 3Confounding variablesIn addition to the time varying exposure to oral antidiabetic drugs and insulin, we included numerous additional confounding variables in the Cox regression models as time fixed variables in the analyses on the basis of the most recent value within one year before starting glucose lowering treatment, as sitagliptin has been shown to alter several potential risk factors.5 The specific variables included were age, sex, socioeconomic status (type of medical insurance and median household income according to the 2010 US census25), clinical laboratory data (glycated hemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, estimated glomerular filtration rate (according to the modified diet in renal disease calculation: 90, 89.9 60, 59.9 30, 26 To further control for comorbidities, we used the adjusted clinical groups score derived from the Johns Hopkins ACG system, version 9,27 which is a single comorbidity score weighted by the 32 adjusted diagnostic groups that performs equally to or better than the Charlson and Elixhauser comorbidity scores.28 In addition, we included the expanded diagnosis cluster for diabetes to further control for diabetes specific complications.27 We also included adherence to glucose lowering treatments in our models by using the medication possession ratio based on the prescription days' supply field.To further control for confounding by indication, we used several techniques.
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